Schedule
| Day | Game | Visitor Team | Score | Home Team | Score | Overtime | Shoot Out | Game Details |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | New Jersey Devils | 3 | Buffalo Sabres | 1 | - | - | Scores |
| 2 | 2 | Buffalo Sabres | 1 | New Jersey Devils | 2 | True | - | Scores |
| 7 | 12 | Los Angeles Kings | 2 | Buffalo Sabres | 3 | - | - | Scores |
| 9 | 25 | Florida Panthers | 3 | Buffalo Sabres | 4 | - | - | Scores |
| 13 | 57 | Buffalo Sabres | 1 | Pittsburgh Penguins | 2 | - | - | Scores |
| 14 | 67 | Buffalo Sabres | 0 | Columbus Blue Jackets | 1 | - | - | Scores |
| 16 | 85 | Buffalo Sabres | 2 | Chicago Blackhawks | 3 | - | - | Scores |
| 19 | 95 | Dallas Stars | 1 | Buffalo Sabres | 2 | - | - | Scores |
| 23 | 122 | Detroit Red Wings | 0 | Buffalo Sabres | 3 | - | - | Scores |
| 25 | 140 | Florida Panthers | 2 | Buffalo Sabres | 1 | - | - | Scores |
| 29 | 169 | New York Islanders | 2 | Buffalo Sabres | 3 | - | - | Scores |
| 30 | 179 | Buffalo Sabres | 3 | Detroit Red Wings | 0 | - | - | Scores |
| 33 | 194 | Ottawa Senators | 5 | Buffalo Sabres | 3 | - | - | Scores |
| 35 | 213 | Buffalo Sabres | 3 | New York Rangers | 4 | - | - | Scores |
| 37 | 224 | Calgary Flames | 2 | Buffalo Sabres | 0 | - | - | Scores |
| 39 | 239 | Montreal Canadiens | 3 | Buffalo Sabres | 4 | - | - | Scores |
| 42 | 257 | St. Louis Blues | 2 | Buffalo Sabres | 3 | True | - | Scores |
| 44 | 278 | Buffalo Sabres | 1 | Philadelphia Flyers | 3 | - | - | Scores |
| 48 | 305 | Buffalo Sabres | 3 | Los Angeles Kings | 1 | - | - | Scores |
| 50 | 317 | Buffalo Sabres | 3 | Anaheim Ducks | 2 | True | True | Scores |
| 51 | 331 | Buffalo Sabres | 2 | San Jose Sharks | 1 | - | - | Scores |
| 55 | 347 | Minnesota Wild | 6 | Buffalo Sabres | 4 | - | - | Scores |
| 57 | 364 | Vancouver Canucks | 2 | Buffalo Sabres | 5 | - | - | Scores |
| 58 | 383 | Buffalo Sabres | 3 | New York Islanders | 2 | - | - | Scores |
| 61 | 397 | Colorado Avalanche | 1 | Buffalo Sabres | 0 | - | - | Scores |
| 63 | 410 | Winnipeg Jets | 5 | Buffalo Sabres | 1 | - | - | Scores |
| 65 | 426 | Utah Hockey Club | 2 | Buffalo Sabres | 1 | - | - | Scores |
| 67 | 443 | Detroit Red Wings | 1 | Buffalo Sabres | 5 | - | - | Scores |
| 69 | 457 | New York Rangers | 2 | Buffalo Sabres | 4 | - | - | Scores |
| 72 | 480 | Buffalo Sabres | 4 | Washington Capitals | 1 | - | - | Scores |
| 73 | 490 | Buffalo Sabres | 2 | Toronto Maple Leafs | 3 | - | - | Scores |
| 75 | 497 | Buffalo Sabres | 3 | Montreal Canadiens | 1 | - | - | Scores |
| 78 | 521 | Toronto Maple Leafs | 2 | Buffalo Sabres | 3 | - | - | Scores |
| 79 | 531 | Buffalo Sabres | 2 | Boston Bruins | 1 | - | - | Scores |
| 81 | 552 | Buffalo Sabres | 2 | New York Islanders | 1 | - | - | Scores |
| 85 | 558 | Chicago Blackhawks | 1 | Buffalo Sabres | 2 | - | - | Scores |
| 87 | 582 | Buffalo Sabres | 2 | St. Louis Blues | 3 | True | True | Scores |
| 89 | 595 | Buffalo Sabres | 4 | Dallas Stars | 2 | - | - | Scores |
| 91 | 610 | Buffalo Sabres | 1 | Colorado Avalanche | 2 | - | - | Scores |
| 93 | 630 | Buffalo Sabres | 4 | Vegas Golden Knights | 5 | True | True | Scores |
| 95 | 637 | Washington Capitals | 2 | Buffalo Sabres | 1 | True | True | Scores |
| 98 | 654 | Buffalo Sabres | 2 | Ottawa Senators | 1 | - | - | Scores |
| 100 | 670 | Seattle Kraken | 1 | Buffalo Sabres | 3 | - | - | Scores |
| 104 | 705 | Carolina Hurricanes | 2 | Buffalo Sabres | 3 | True | - | Scores |
| 106 | 720 | Pittsburgh Penguins | 0 | Buffalo Sabres | 2 | - | - | Scores |
| 109 | 742 | Buffalo Sabres | 0 | Seattle Kraken | 0 | - | - | |
| 110 | 755 | Buffalo Sabres | 0 | Vancouver Canucks | 0 | - | - | |
| 112 | 767 | Buffalo Sabres | 0 | Calgary Flames | 0 | - | - | |
| 114 | 777 | Buffalo Sabres | 0 | Edmonton Oilers | 0 | - | - | |
| 117 | 799 | Boston Bruins | 0 | Buffalo Sabres | 0 | - | - | |
| 120 | 822 | Nashville Predators | 0 | Buffalo Sabres | 0 | - | - | |
| 122 | 835 | New Jersey Devils | 0 | Buffalo Sabres | 0 | - | - | |
| 124 | 846 | Columbus Blue Jackets | 0 | Buffalo Sabres | 0 | - | - | |
| 128 | 885 | Buffalo Sabres | 0 | Nashville Predators | 0 | - | - | |
| 142 | 895 | New York Rangers | 0 | Buffalo Sabres | 0 | - | - | |
| 145 | 919 | Anaheim Ducks | 0 | Buffalo Sabres | 0 | - | - | |
| 147 | 940 | Buffalo Sabres | 0 | Carolina Hurricanes | 0 | - | - | |
| 149 | 953 | Montreal Canadiens | 0 | Buffalo Sabres | 0 | - | - | |
| 151 | 968 | Buffalo Sabres | 0 | Montreal Canadiens | 0 | - | - | |
| 152 | 974 | San Jose Sharks | 0 | Buffalo Sabres | 0 | - | - | |
| 154 | 989 | Buffalo Sabres | 0 | Tampa Bay Lightning | 0 | - | - | |
| 156 | 1006 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 158 | 1021 | Edmonton Oilers | 0 | Buffalo Sabres | 0 | - | - | |
| 160 | 1036 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 163 | 1055 | Vegas Golden Knights | 0 | Buffalo Sabres | 0 | - | - | |
| 165 | 1073 | Buffalo Sabres | 0 | Boston Bruins | 0 | - | - | |
| 168 | 1100 | Buffalo Sabres | 0 | Utah Hockey Club | 0 | - | - | |
| 170 | 1106 | Buffalo Sabres | 0 | Minnesota Wild | 0 | - | - | |
| 171 | 1119 | Buffalo Sabres | 0 | Winnipeg Jets | 0 | - | - | |
| 173 | 1129 | Ottawa Senators | 0 | Buffalo Sabres | 0 | - | - | |
| 175 | 1143 | Pittsburgh Penguins | 0 | Buffalo Sabres | 0 | - | - | |
| 177 | 1159 | Buffalo Sabres | 0 | Philadelphia Flyers | 0 | - | - | |
| 178 | 1171 | Buffalo Sabres | 0 | Washington Capitals | 0 | - | - | |
| 180 | 1184 | Buffalo Sabres | 0 | Ottawa Senators | 0 | - | - | |
| 184 | 1215 | Tampa Bay Lightning | 0 | Buffalo Sabres | 0 | - | - | |
| 185 | 1226 | Boston Bruins | 0 | Buffalo Sabres | 0 | - | - | |
| 187 | 1235 | Carolina Hurricanes | 0 | Buffalo Sabres | 0 | - | - | |
| 189 | 1253 | Buffalo Sabres | 0 | Columbus Blue Jackets | 0 | - | - | |
| 191 | 1268 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 192 | 1280 | Buffalo Sabres | 0 | Tampa Bay Lightning | 0 | - | - | |
| 194 | 1292 | Toronto Maple Leafs | 0 | Buffalo Sabres | 0 | - | - | |
| 196 | 1307 | Philadelphia Flyers | 0 | Buffalo Sabres | 0 | - | - |